Services
hERG
What does this current do?
- The hERG current is largely responsible for repolarization of the myocardium
- Blockade results in QT prolongation and potential arrhythmia (torsade de pointe)
Why test it?
- Required for ICH IND submissions
Study types:
- Non-GLP screening
- GLP study
- ICH Best Practices study design — recommended to avoid the need to repeat assay in the future
For more information:
Peak Nav1.5
What does this current do?
- The Peak Nav1.5 current is responsible for conduction throughout the myocardium
- Blockade of this current can result in QRS prolongation
Why test it?
- To characterize a drug's risk of QRS prolongation and potential ventricular arrhythmias
Study types:
- Non-GLP screening
- GLP study
- ICH Best Practices study design — recommended to avoid the need to repeat assay in the future
For more information:
Late Nav1.5
What does this current do?
- The Late Nav1.5 current plays a role in action potential duration and the QT interval
Why test it?
- Blockade of this current can offset hERG blockade and minimize QT interval prolongation
Study types:
- Non-GLP screening
- GLP study
- ICH Best Practices study design — recommended to avoid the need to repeat assay in the future
For more information:
Cav1.2
What does this current do?
- Cav1.2 plays a role in action potential duration and the QT interval
- Provides insight into the hemodynamic function
Why test it?
- Blockade of this current can offset hERG blockade and minimize QT interval prolongation
- Blockade can cause PR interval prolongation and decreases in blood pressure
Study types:
- Non-GLP screening
- GLP study
- ICH Best Practices study design — recommended to avoid the need to repeat assay in the future
For more information:
Other Ion Channels
| Ion Channels | Test System | Ion Channels | Test System |
|---|---|---|---|
| Nav1.1 | HEK293 | Kir1.1 | HEK293 |
| Nav1.3 | HEK293 | Kir2.1 | HEK293 |
| Nav1.4 | HEK293 | Kir4.1 | HEK293 |
| Nav1.5 | HEK293 | Kir6.1 | HEK293 |
| Nav1.6 | HEK293 | KCNQ1 | HEK293 |
| Nav1.7 | HEK293 | KCNQ2 | HEK293 |
| Nav1.8 | rat DRG | KCNQ4 | HEK293 |
| Nav1.9 | rat DRG | Cav1.2 | HEK293 |
| hERG | HEK293 | Cav3.1 | HEK293 |
| HCN1 | HEK293 | Cav3.2 | HEK293 |
| HCN2 | HEK293 | Cav3.3 | HEK293 |
| HCN3 | HEK293 | CFTR | HEK293 |
| HCN4 | HEK293 | GABAa a1,β2,γ2 | HEK293T |
| Kv1.3 | CHO | BK | HEK293 |
| Kv1.4 | HEK293 | Asic1 | HEK293 |
| Kv1.5 | HEK293 | Asic2 | HEK293 |
| Kv1.6 | HEK293 | Asic3 | HEK293 |
| Kv1.7 | HEK293 | Twik1 | HEK293 |
| Kv1.8 | HEK293 | TRPA1 | HEK293 |
| Kv2.1 | HEK293 | TRPC6 | HEK293 |
| Kv3.1 | HEK293 | TRPV6 | CHO |
| Kv3.2 | HEK293 | P2x7 | 1321N1 |
| Kv4.2 | HEK293 | P2x3 | 1321N1 |
| Kv4.3 | HEK293 | P2x2/3 | 1321N1 |
