The function of the hERG current is to repolarize the myocardium. Blockade results in QT prolongation and potential arrhythmia (torsade de pointe). Evaluation of drug effects on hERG current is required for IND submission.
Adhering to Global Regulatory Guidelines, the Nova Research Laboratory Analytic Services Department offers capabilities to develop, qualify, and validate analytical methods in the support of non-clinical dose formulation analyses for all in-vivo, ex-vivo, or in-vitro platforms.
The Nova team has developed a highly predictive model for detecting QTc changes using ion channel data, known as QT Fingerprinting.
Completed GLP Studies
Nova Research Laboratories is the top provider of ion channel research in the United States. Along with offering unparalleled expertise in the field, we are committed to going above and beyond to ensure that we meet or exceed sponsor timelines. We offer individualized attention to our clients to both deliver and interpret data for a successful IND package.