Allosteric effects of erythromycin pretreatment on thioridazine block of hERG potassium channels

Many different drug classes and structures are associated with cardiac QT prolongation. The most common underlying mechanism for this QT prolongation is block of the rapid component of the delayed rectifier current IKR, which in humans is carried by the protein product of the human ether-a-go-go-related (hERG) gene (the Kv11.x channels; channel nomenclature follows Alexander et al., 2013).